Definition of Waldenstrom macroglobulinemia
Waldenstrom macroglobulinemia (mak-ro-glob-u-lih-NEE-me-uh), also called WM or lymphoplasmacytic lymphoma, is a type of non-Hodgkin’s lymphoma (also called non-Hodgkin lymphoma). WM is a rare, slow-growing cancer that begins in the immune system. Abnormal white blood cells (lymphocytes) in the bone marrow make an abnormal protein called monoclonal immunoglobulin M (IgM) that thickens the blood plasma. This causes the symptoms of WM.
The most common signs and symptoms include fatigue, nosebleeds, dizziness, gum bleeding, weight loss, bruising, headache, and numbness or tingling in your hands or feet. Your doctor may also find enlarged lymph glands in your neck, groin or under your arms.