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Agrylin – Anagrelide (Oral Route)


Description and Brand Names of Agrylin – Anagrelide (Oral Route)

US Brand Name

  1. Agrylin


Anagrelide is used to decrease the risk of blood clots in patients who have thrombocythemia (too many platelets in the blood). It works to decrease production of platelets in the body.

This medicine is available only with your doctor’s prescription.

This product is available in the following dosage forms:

  • Capsule

Before Using Agrylin – Anagrelide (Oral Route)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of anagrelide in children.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of anagrelide in the elderly.



There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Piperaquine
  • Riociguat

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alipogene Tiparvovec
  • Apixaban
  • Aspirin
  • Crizotinib
  • Desvenlafaxine
  • Dipyridamole
  • Duloxetine
  • Eptifibatide
  • Fluoxetine
  • Ivabradine
  • Levomilnacipran
  • Milnacipran
  • Ondansetron
  • Pazopanib
  • Quetiapine
  • Vemurafenib
  • Venlafaxine
  • Vinflunine
  • Vortioxetine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aspirin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Congestive heart failure, history of or
  • Heart disease, history of or
  • Heart rhythm problems, history of or
  • Lung disease (eg, interstitial lung disease), history of – Use with caution. May make these conditions worse.
  • Liver disease, mild or moderate – Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Liver disease, severe – Should not be used in patients with this condition.

Proper Use of Agrylin – Anagrelide (Oral Route)

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects.

You may take this medicine with or without food.


The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):

    • For thrombocythemia:

      • Adults – At first, 0.5 milligram (mg) four times a day or 1 mg two times a day. Your doctor may adjust your dose if needed.
      • Children – At first, 0.5 mg per day. Your doctor may adjust your dose if needed.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.


It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly. Blood tests are needed to check for unwanted effects.

This medicine may cause unwanted effects on the heart. Check with your doctor right away if you or your child have chest pain, tightness, or discomfort, decreased urine output, dilated neck veins, extreme fatigue, a fast, pounding, or uneven heartbeat or pulse, pain or discomfort in the arms, jaw, back or neck, nausea or vomiting, sweating, swelling of the face, fingers, feet, or lower legs, trouble breathing, or weight gain. These could be symptoms of a serious heart problem.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, a loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Check with your doctor right away if you or your child have breathing problems, a cough, a fever, a fast heartbeat, or shortness of breath. These could be symptoms of a serious lung problem.

Do not stop using this medicine suddenly without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely. To do so will cause the platelet level in your blood to increase quickly.

Do not take aspirin or aspirin-containing products since they may also affect your platelets. Do not take any other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of Agrylin – Anagrelide (Oral Route)

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Bloating or swelling of the face, arms, hands, lower legs, or feet
  2. body aches or pain
  3. burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  4. chest pain
  5. congestion
  6. cough
  7. difficult or labored breathing
  8. dryness or soreness of the throat
  9. fast, irregular, pounding, or racing heartbeat or pulse
  10. fever
  11. hoarseness
  12. rapid weight gain
  13. runny nose
  14. shortness of breath
  15. tender, swollen glands in the neck
  16. tightness in the chest
  17. trouble with swallowing
  18. voice changes

Less common

  1. Anxiety
  2. blurred vision
  3. burning while urinating
  4. chills
  5. cold sweats
  6. confusion
  7. decreased urine output
  8. dehydration
  9. difficult or painful urination
  10. dilated neck veins
  11. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  12. extreme fatigue
  13. general feeling of discomfort or illness
  14. headache
  15. irregular breathing
  16. joint pain
  17. large, flat, blue, or purplish patches in the skin
  18. loss of appetite
  19. muscle aches and pains
  20. nausea or vomiting
  21. nervousness
  22. noisy breathing
  23. pale skin
  24. redness of the face, neck, arms, and occasionally, upper chest
  25. severe pain or pressure in the chest or the jaw, neck, back, or arms
  26. shortness of breath
  27. sudden severe headache or weakness
  28. swollen, painful, or tender lymph glands in the neck, armpit, or groin
  29. trouble sleeping
  30. troubled breathing with exertion
  31. unusual bleeding or bruising
  32. unusual tiredness or weakness
  33. vomiting of blood or material that looks like coffee grounds
  34. weight gain

Incidence not known

  1. Abdominal or stomach pain or tenderness
  2. clay colored stools
  3. dark urine
  4. decreased appetite
  5. dry cough
  6. general feeling of tiredness or weakness
  7. itching
  8. rapid breathing
  9. skin rash
  10. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Acid or sour stomach
  2. back pain
  3. belching
  4. diarrhea
  5. excess air or gas in the stomach or intestines
  6. full feeling
  7. general feeling of discomfort or illness
  8. heartburn
  9. hives or welts
  10. indigestion
  11. lack or loss of strength
  12. loss of appetite
  13. pain
  14. passing gas
  15. stomach discomfort, upset, or pain

Less common

  1. Burning feeling in the chest or stomach
  2. change in vision
  3. confusion
  4. constipation
  5. continuing ringing or buzzing or other unexplained noise in the ears
  6. depression
  7. difficulty with moving
  8. double vision
  9. hair loss or thinning of the hair
  10. hearing loss
  11. impaired vision
  12. increased sensitivity of the skin to sunlight
  13. leg cramps
  14. loss of memory
  15. muscle pain or stiffness
  16. nervousness
  17. problems with memory
  18. redness or other discoloration of the skin
  19. seeing double
  20. severe sunburn
  21. sleepiness or unusual drowsiness
  22. stuffy nose
  23. swelling or inflammation of the mouth
  24. swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.