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Ativan – Lorazepam (Oral Route)


Description and Brand Names of Ativan – Lorazepam (Oral Route)

US Brand Name

  1. Ativan
  2. Lorazepam Intensol


Lorazepam is used to treat anxiety. This medicine is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor’s prescription.

This product is available in the following dosage forms:

  • Tablet
  • Solution

Before Using Ativan – Lorazepam (Oral Route)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of lorazepam in children under 12 years of age. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lorazepam in the elderly. However, severe drowsiness or unsteadiness are more likely to occur in the elderly, who are usually more sensitive than younger adults to the effects of lorazepam. Elderly patients may require a lower dose to help reduce unwanted effects.



Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfentanil
  • Amobarbital
  • Anileridine
  • Aprobarbital
  • Butabarbital
  • Butalbital
  • Carbinoxamine
  • Carisoprodol
  • Chloral Hydrate
  • Chlorzoxazone
  • Codeine
  • Dantrolene
  • Ethchlorvynol
  • Fentanyl
  • Fospropofol
  • Hydrocodone
  • Hydromorphone
  • Levorphanol
  • Meclizine
  • Meperidine
  • Mephenesin
  • Mephobarbital
  • Meprobamate
  • Metaxalone
  • Methocarbamol
  • Methohexital
  • Morphine
  • Morphine Sulfate Liposome
  • Orlistat
  • Oxycodone
  • Oxymorphone
  • Pentobarbital
  • Phenobarbital
  • Primidone
  • Propoxyphene
  • Remifentanil
  • Secobarbital
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Thiopental
  • Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Perampanel
  • Posaconazole
  • Probenecid
  • Pyrimethamine
  • St John’s Wort
  • Theophylline
  • Valproic Acid

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Glaucoma, acute narrow-angle – Should not be used in patients with this condition.
  • Kidney disease or
  • Liver disease – Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Lung diseases (e.g., COPD, sleep apnea syndrome) or
  • Seizures – Use with caution. May make these conditions worse.

Proper Use of Ativan – Lorazepam (Oral Route)

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral solution:

This medicine is to be taken by mouth. Measure the oral liquid with the provided medicine dropper. Dilute each dose with water, juice, soda, applesauce and puddings.


The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (tablets or solution):

    • For anxiety:

      • Adults or teenagers – 2 to 6 milligrams (mg) in divided doses per day. Your doctor may adjust your dose as needed.
      • Older adults – At first, 1 to 2 mg in divided doses per day. Your doctor may adjust your dose as needed.
      • Children younger than 12 years of age – Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.


It is very important that your doctor check your progress at regular visits to allow for changes in your dose and to check for any unwanted effects. Blood tests may be needed to check for any unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause drowsiness, trouble with thinking, trouble with controlling movements, or trouble with seeing clearly. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to think or see well.

Do not stop taking it without checking with your doctor first. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), hallucinations, stomach or muscle cramps, tremors, or unusual behavior.

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates (used for seizures); muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you stop taking this medicine. Check with your doctor before taking any of the above while you are using this medicine.

Side Effects of Ativan – Lorazepam (Oral Route)

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Drowsiness
  2. relaxed and calm
  3. sleepiness

Incidence not known

  1. Abdominal or stomach pain
  2. aggressive, angry
  3. agitation
  4. anxiety
  5. attack, assault, or force
  6. black, tarry stools
  7. bleeding gums
  8. blood in urine or stools
  9. bluish lips or skin
  10. blurred vision
  11. change in consciousness
  12. chills
  13. coma
  14. confusion
  15. confusion about identity, place, and time
  16. convulsions
  17. cough or hoarseness
  18. dark urine
  19. decreased urine output
  20. difficulty in breathing and/or swallowing
  21. difficulty in speaking
  22. discouragement
  23. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  24. drooling
  25. dry mouth
  26. excitation
  27. false or unusual sense of well-being
  28. fast or irregular heartbeat
  29. fear or nervousness
  30. feeling sad or empty
  31. fever with or without chills
  32. general feeling of tiredness or weakness
  33. headache
  34. hives
  35. hyperventilation
  36. increased thirst
  37. irregular, fast or slow, or shallow breathing
  38. irritability
  39. itching
  40. loss of appetite
  41. loss of balance control
  42. loss of consciousness
  43. loss of interest or pleasure
  44. loss of memory
  45. lower back or side pain
  46. muscle pain or cramps
  47. muscle trembling, jerking, or stiffness
  48. nausea or vomiting
  49. not breathing
  50. painful or difficult urination
  51. pale or blue lips, fingernails, or skin
  52. pinpoint red spots on skin
  53. problems with memory
  54. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  55. rash
  56. reddening of the skin, especially around ears
  57. restlessness
  58. seeing, hearing, or feeling things that are not there
  59. seizures
  60. shaking
  61. shortness of breath
  62. shuffling walk
  63. sleeplessness
  64. sore throat
  65. sores, ulcers, or white spots on lips or in mouth
  66. stiffness of limbs
  67. sweating
  68. swelling of eyes or inside of nose
  69. swelling of face, ankles, or hands
  70. swollen glands
  71. thoughts or attempts at killing oneself
  72. tightness in chest
  73. trouble concentrating
  74. trouble sleeping
  75. twisting movements of body
  76. unable to sleep
  77. uncontrolled movements, especially of face, neck, and back
  78. unexplained bleeding or bruising
  79. unpleasant breath odor
  80. unusual bleeding or bruising
  81. unusual tiredness or weakness
  82. vomiting of blood
  83. wheezing
  84. yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Changes in patterns and rhythms of speech
  2. increased sweating
  3. loss of strength or energy
  4. low blood pressure
  5. nightmares
  6. shakiness and unsteady walk
  7. slurred speech
  8. trouble in speaking
  9. unsteadiness, trembling, or other problems with muscle control or coordination
  10. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  11. unusual excitement, nervousness, restlessness, or irritability
  12. unusual paleness unusual weak feeling

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Being forgetful
  2. clumsiness
  3. constipation
  4. decreased interest in sexual intercourse
  5. disturbed color perception
  6. dizziness or lightheadedness
  7. double vision
  8. drowsiness
  9. feeling of constant movement of self or surroundings
  10. hair loss, thinning of hair
  11. halos around lights
  12. hostility
  13. inability to have or keep an erection
  14. increased in sexual ability, desire, drive, or performance
  15. increased interest in sexual intercourse
  16. lack or loss of self-control
  17. lethargy
  18. loss in sexual ability, desire, drive, or performance
  19. low body temperature
  20. muscle aches
  21. muscle twitching
  22. muscle weakness
  23. night blindness
  24. overbright appearance of lights
  25. rapid weight gain
  26. sensation of spinning
  27. shakiness in legs, arms, hands, or feet
  28. shivering
  29. sleepiness
  30. stupor
  31. trembling or shaking of hands or feet
  32. tunnel vision
  33. weak or feeble pulse

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.