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Conivaptan (Intravenous Route)


Description and Brand Names of Conivaptan (Intravenous Route)

US Brand Name

  1. Vaprisol


Conivaptan is used to treat euvolemic hyponatremia (a condition where there is not enough sodium in your blood but with a normal blood volume). Sodium is a chemical that the body needs to be able to function well. Even if there is a normal blood volume, but with a low sodium level, it can still be a danger to your health. Conivaptan works by maintaining the right amount of sodium that the body needs .

This medicine is available only with your doctor’s prescription .

This product is available in the following dosage forms:

  • Solution

Before Using Conivaptan (Intravenous Route)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of conivaptan in the pediatric population. Safety and efficacy have not been established .


Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of conivaptan in the elderly .



There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Clarithromycin
  • Cobicistat
  • Indinavir
  • Itraconazole
  • Ivabradine
  • Ketoconazole
  • Lomitapide
  • Lurasidone
  • Maraviroc
  • Nimodipine
  • Ritonavir

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ado-Trastuzumab Emtansine
  • Afatinib
  • Amiodarone
  • Amlodipine
  • Apixaban
  • Artemether
  • Atorvastatin
  • Avanafil
  • Axitinib
  • Bedaquiline
  • Bosutinib
  • Cabozantinib
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Digoxin
  • Domperidone
  • Enzalutamide
  • Eslicarbazepine Acetate
  • Fentanyl
  • Fluticasone
  • Hydrocodone
  • Ibrutinib
  • Ivacaftor
  • Levomilnacipran
  • Lovastatin
  • Lumefantrine
  • Macitentan
  • Midazolam
  • Mifepristone
  • Nilotinib
  • Piperaquine
  • Pixantrone
  • Pomalidomide
  • Ponatinib
  • Primidone
  • Quetiapine
  • Regorafenib
  • Retapamulin
  • Rivaroxaban
  • Romidepsin
  • Ruxolitinib
  • Simeprevir
  • Simvastatin
  • Sunitinib
  • Tamsulosin
  • Trabectedin
  • Vemurafenib
  • Vilanterol
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vinflunine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Hypovolemic hyponatremia (low blood sodium with low blood volume) – This medicine should NOT be used in patients with this condition .
  • Heart disease (e.g., congestive heart failure) – Use with caution. This medicine may make the condition worse .
  • Liver disease or
  • Kidney disease – Use with caution. These conditions may increase the concentration of conivaptan in your blood .

Proper Use of Conivaptan (Intravenous Route)

A nurse or other trained health professional will give you this medicine. Make sure that the infusion site be changed every 24 hours to prevent irritation. If you still have the needle placed on the same site after 24 hours, tell your doctor or nurse .


The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:

    • For treatment of euvolemic hyponatremia:

      • Adults – At first, 20 milligrams (mg) administered over 30 minutes. Then, another 20 mg infused continuously for 24 hours. After the initial day of treatment, conivaptan may be given for another 1 to 3 days in a continuous infusion of 20 mg per day. All doses of conivaptan are diluted prior to injection into a vein. Your doctor may increase the dose if needed.
      • Children – Use and dose must be determined by your doctor .


It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it .

If your symptoms do not improve within a few days or if they become worse, check with your doctor .

You should not use any of the following medicines while you are using conivaptan :

  • Clarithromycin (e.g., Biaxin®).
  • Indinavir (e.g., Crixivan®).
  • Itraconazole (e.g., Sporanox®).
  • Ketoconazole (e.g., Nizoral®).
  • Ritonavir (e.g., Norvir®) .

Side Effects of Conivaptan (Intravenous Route)

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More Common

  1. Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at site
  2. bloating or swelling of face, arms, hands, lower legs, ankles, or feet
  3. blurred vision
  4. decreased urine
  5. dizziness
  6. dry mouth
  7. headache
  8. increased thirst
  9. irregular heartbeat
  10. loss of appetite
  11. mood changes
  12. muscle pain or cramps
  13. nausea or vomiting
  14. nervousness
  15. numbness or tingling in hands, feet, or lips
  16. pounding in the ears
  17. rapid weight gain
  18. seizures
  19. shortness of breath
  20. slow or fast heartbeat
  21. tingling of hands or feet
  22. unusual tiredness or weakness
  23. unusual weight gain or loss

Less Common

  1. Abdominal pain
  2. bladder pain
  3. bloody or cloudy urine
  4. bluish color
  5. change in consciousness
  6. changes in skin color
  7. chest pain
  8. cold sweats
  9. confusion
  10. cool pale skin
  11. cough
  12. decreased urination
  13. depression
  14. difficult, burning, or painful urination
  15. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  16. drowsiness
  17. fainting
  18. fear
  19. fever or chills
  20. flushed, dry skin
  21. frequent urge to urinate
  22. fruit-like breath odor
  23. increase in amount of urine
  24. increase in heart rate
  25. increased hunger
  26. increased urination
  27. loss of consciousness
  28. lower back or side pain
  29. mental changes
  30. muscle spasms [tetany] or twitching
  31. nightmares
  32. pale skin
  33. problems in urination
  34. rapid breathing
  35. shakiness
  36. sleeplessness
  37. slurred speech
  38. sneezing
  39. sore mouth or tongue
  40. sore throat
  41. sunken eyes
  42. sweating
  43. swelling of foot or leg
  44. tenderness
  45. thirst
  46. tightness in chest
  47. trembling
  48. trouble sleeping
  49. troubled breathing with exertion
  50. unable to sleep
  51. unusual bleeding or bruising
  52. wheezing
  53. white patches in mouth and/or on tongue
  54. wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  1. Diarrhea

Less Common

  1. Difficulty having a bowel movement (stool)
  2. flushing
  3. redness of skin
  4. unusually warm skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.